Meet our investigators at the Cardiovascular Research Center.
David Goukassian MD, PhD - | Director of CVRC, Principal Investigator. Associate Professor of Medicine, Tufts University School of Medicine; Head, Vascular Biology and Space Radiation Research.
Dr. David Goukassian joined the faculty of Cardiovascular Research Division at St. Elizabeth’s Medical Center in 2001 from the Departments of Dermatology and Medicine at Boston University School of Medicine where he was Associate Professor of Medicine, Pathology and Dermatology, Head of the Translational Research Section and the Principal Investigator on several projects investigating molecular mechanisms of pathological and therapeutic angiogenesis and translational research of DNA damage and repair using various murine models of human cancer and development of cancer therapeutics (melanoma, lung and breast cancer). His earlier research work was concentrated on the improvement of the age-associated decreases in DNA repair capacity using various knockout and transgenic murine models, human skin 3D organ-cultures and human skin and lung cancer organotypic models.
In the last decade his research work is focused on two seemingly diverse bur overlapping areas – (1) the development of novel anti-cancer treatment modalities based on inhibition of TNF signaling via selective blocking of its receptors (p55 or p75) for treatment of various human tumors including, but not limited to melanoma, breast, and lung cancers; and (2) the role of TNF receptors p55 and p75 signaling in cardiac repair in ischemic tissue, focusing on elucidating the role of ECs and BM-derived EPCs in ischemia-induced cardiac regeneration and post-natal neovascularization (heart and skeletal muscle).
NASA Human Research Program (IRP) identified space IR as one of the space flight risk factors to the CV and circulatory systems. In addition, long-duration space missions such as work on ISS, future lunar, near Earth asteroid, and Mars missions, as well as emerging civilian space travel activities, necessitate ground-based studies on degenerative CV risk assessment of space IR. His current NASA-funded research work is focused in the area of Space Radiobiology, specifically, evaluation of space radiation-induced damage to BM-derived stem and progenitor cells and cardiac ECs and evaluation of space radiation-associated long-term degenerative risks to cardiovascular system.
Xinhua Yan, M.D., M.S. FAHA - | Senior Investigator at Genesys Research Institute. Assistant Professor at Tufts University School of Medicine.
Xinhua Yan is a Senior Investigator of Cardiovascular Research and Assistant Professor at Tufts University School of Medicine. Her research focus is cancer therapy induced cardiotoxicity(Oncocardiology or Cardio-Oncology). Specifically, her research focuses on the role of HER2 and PI3K pathways and the Neuregulin signaling in the heart.
Joseph P. Carrozza, Jr, MD - | Chief of Cardiovascular Medicine, Steward St. Elizabeth's Medical Center, Vice President-Steward Cardiovascular Network. Professor of Medicine, Tufts University School of Medicine.
For the past 25 years I have been actively involved in clinical and translational research as well as the practice of interventional cardiology. Previously, I have served as Director of Interventional Animal Research at Beth Israel Deaconess Medical Center were research interests included excitation-contraction coupling and calcium handling during myocardial stunning, microvascular dysfunction associated with cocaine intoxication, and quantification of acute stent recoil. I have participated in >100 multicenter clinical trials of new devices in Interventional Cardiology, including serving as national principal investigator for 4 trials. More recent interests have included robotic-assisted percutaneous coronary intervention, appropriate use criteria for PCI, and effects of radiation exposure on premature coronary artery disease and vasculopathy.