Sharath is the senior research associate of Dr. Goukassian's lab at the CardioVascular Research Center. He is involved in numerous research focuses ranging in areas of cardiovascular space radiobiology, cancer biology, and molecular cardiology.
John is a student research associate in Dr. Goukassian's lab at the CardioVascular Research Center. He is graduating with a masters degree from the Boston University School of Medicine and plans on matriculating into the Chicago Medical School. He has developed several areas of research interests including focuses in cardiovascular space radiobiology, cancer biology, molecular cardiology, and emergency cardiovascular care/resuscitation.
Medical Resident at St Elizabeth’s Medical Center. Clinical interests are in Cardiovascular Medicine. Research interests include cardiac biomarkers and phospholipid oxidation. Adam has experience with in vivo animal experimental studies.
Clinical resident at Steward Carney Hospital, Tufts University School of Medicine. Broad research focus, ranging from basics science to clinical research investigations.
Cardiology Fellow at St Elizabeth's Medical Center. Clinical and research interest in non-invasive cardiology. Dr. Hagau has a special interest in advanced cardiovascular imaging.
Research in the Kishore laboratory is focused on several specific areas within the overall theme of identifying novel insights into cardiovascular disease mechanisms and the translational integration of mechanistic studies in relevant physiological models. The major focus of ongoing research encompasses multiple aspects of stem cell based therapies for post-infarct myocardial and other ischemic tissue repair and regeneration. The laboratory is currently investing significant efforts on developing novel strategies to enhance the therapeutic benefits of stem cell therapy (of both adult and embryonic/ iPS cells) specifically their survival, function, and differentiation both in vitro and in physiologically relevant in vivo models of myocardial injury. Some of the strategies include epigenetic modifications, use of nano-biomaterials and co-therapy with anti-inflammatory cytokines. The lab is also developing cell-free, stem cell derived exosomes as a viable alternate to cell-based therapies. Another area of major research focus in the Kishore lab is to delineate mechanisms of Interleukin-10 mediated attenuation of cardiovascular injury and inflammation.
The research program of my laboratory is dedicated to defining the molecular mechanisms that underlie cardiovascular biology and contribute to the recovery from cardiovascular disease, and to translating the results from these basic science investigations to clinical applications. A portion of his research focuses on the transcriptional networks and genetic pathways that control the growth and function of blood vessels under both physiological and pathological conditions, with particular attention devoted to the involvement of the E2F transcription factors in ischemic angiogenesis and blood pressure regulation. I am also committed to improving the effectiveness of stem- and progenitor-cell therapy for the treatment of ischemic disease by characterizing the molecular interactions between various stem-cell populations (e.g., bone-marrow derived stem/progenitor cells, cardiac progenitor cells) and their microenvironment, and by investigating the genetic and epigenetic mechanisms that govern the differentiation of embryonic and induced-pluripotent stem (ES and iPS) cells.
The area of scientific interest is Genitourinary Pathology and Molecular Biology. Main focus of research is mechanisms of prostatic neoplasia, renal cancerogenesis and morphogeneisis, biomolecular markers of tumor development, progression and clinico-pathologic characteristics. For more than 20 years I have been interested in radiation-induced pathology, studying influence of small doses of incorporated radionuclides on morpho-functional status of human tissues.
Dr. Enderling is a computer scientist turned mathematical biologist, who is interested in mathematical and computational models of cancer dynamics, with focus on cancer stem cells and non-stem cancer cell interactions.
The Enderling lab uses a variety of tools to explore stem cell kinetics, development and tumor growth dynamics. Primarily the lab uses agent-based models and differential equations to describe single cell and population level dynamics and simulate diffusion of soluable factors used by cells to grow and communicate with each other. The aim is to thoroughly investigate physiological development as well as tumor growth and progression to design novel treatment approach
Jin is a research associate, having completed his thesis in the lab for the completion of a masters degree at Boston University School of Medicine in 2014. He is currently a medical student at Nova Southeastern University College of Osteopathic Medicine with an interest in cardiovascular and cancer research.
Layla is an MS candidate at Boston University School of Medicine currently working on her thesis. She is contributing in numerous ongoing projects in the lab.
Dr. JuYong Lee is an assistant professor in the Department of Medicine at UConn Health Calhoun Cardiology Center. Dr. Lee is an interventional cardiologist with experience in treating coronary artery disease, peripheral artery disease, and structural heart disease. He is a member of American College of Cardiology and American Heart Association.